The conversation revolves around the unexpected selection of an American Pope, with Matt Gagnon explaining the rarity of such a choice due to America’s global influence. He mentions following a Twitter account, “Pope Predictor,” which uses an algorithm to evaluate cardinals’ “poppability” based on factors like age, geographical origin, and positions held. Despite the algorithm not initially predicting an American Pope, it identified Cardinal Prevost as a top contender. Prevost, known for his centrist views, was eventually chosen as the new Pope. The discussion also touches on the algorithm’s creator’s anonymity and growing popularity.